A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Organ-specific or personalized treatment for COVID-19: rationale, evidence, and potential candidatesArticle Published on 2022-06-012022-10-04 Journal: Functional & integrative genomics [Category] COVID19(2023년), SARS, 신약개발, [키워드] A549 acute respiratory syndrome analyzed biological pathway candidate Cell Complication coronavirus coronavirus disease COVID-19 DEGs differentially expressed gene Drug repurposing drug repurposing. effective Evidence experiment extrapulmonary organ FDA-approved drug Genes increasingly infected cell involved liver lung alveolar manifestation Multiorgan multisystemic network analysis organ organ-specific Organ-specific treatment Organoid organs Pathogenesis pathophysiology Pathway enrichment analysis Personalized medicine pluripotent stem cell PPI protein-protein interaction reported responsible SARS-CoV-2 SARS-COV-2 infection therapeutic therapeutic strategy therapy Treatment was done were used [DOI] 10.1007/s10142-022-00841-z PMC 바로가기 [Article Type] Article
Designing of a bispecific antibody against SARS-CoV-2 spike glycoprotein targeting human entry receptors DPP4 and ACE2인간 진입 수용체 DPP4 및 ACE2를 표적으로 하는 SARS-CoV-2 스파이크 당단백질에 대한 이중특이성 항체 설계Article Published on 2022-04-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] ACE2 Anti-viral antibody binding affinity Bispecific Antibody (BsAb) block China cleavage condition COVID-19 CrossMAb D614G disease DPP4 entry receptor epithelial cells Fc region global pandemic glycoprotein hACE2 hACE2 receptor heavy chain Host in-silico Infection KIH light chain linker lung alveolar lung alveolar epithelial cells modifications Molecular docking study mutated peptide performed Prevent receptor receptor engagement receptors regdanvimab Research SARS-CoV-2 SARS-CoV-2 spike glycoprotein spike spike glycoprotein spike glycoprotein. Spike protein therapeutic target therapy Viral viral entry viral spike viral spike protein virus Wuhan [DOI] 10.1016/j.humimm.2022.01.004 PMC 바로가기 [Article Type] Article
Computational Methods to Study Human Transcript Variants in COVID-19 Infected Lung Cancer CellsCOVID-19에 감염된 폐암 세포에서 인간 전사체 변이체를 연구하기 위한 전산 방법Article Published on 2021-09-072022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 3′-UTR A549 addition Alter alternative polyadenylation alternative splicing Analysis APA applied biological pathway cells Combination computational method Computational methods correlation COVID-19 COVID-19 pandemic Data analysis detect Differential gene expression differential gene expression analysis differentially expressed event events host transcriptome Human indicate Infection lab lead lung alveolar microbes mock-treated molecular molecular mechanism pathway Pathways Regulation Research RNA-Seq RNA-seq data SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 pathogenesis the disease transcript transcript variants Transcriptome transcriptomes variant virus viruses [DOI] 10.3390/ijms22189684 PMC 바로가기 [Article Type] Article
Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 InfectionArticle Published on 2021-08-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] A549 acute respiratory syndrome Algorithm Analysis applied biological process Biomarkers Bronchial epithelium bronchial epithelium cells candidate drugs categories caused Cell cell line cells clinical trial co-expression network Combined conducted coronavirus correlated COVID-19 COVID-19 infection COVID-19 patient Defense disease drug drug target effective enrichment analysis evaluate Explainable artificial intelligence gene co-expression network gene signature HEPHL1 human lung epithelium IL-17 in vitro in vivo Infection KEGG pathway lung alveolar machine learning module network NHBE pandemic pathogenesis of COVID-19 pathogenicity pathway PGLYRP4 prognostic Regulation SARS-CoV-2 signaling pathway significantly therapeutic approaches therapeutic targets transcriptional change transcriptional profiling translational treat Treatment type I interferon Vaccine validation viral infection virus WGCNA [DOI] 10.3390/jcm10163567 PMC 바로가기 [Article Type] Article
Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine StormReview Published on 2021-04-292022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Activation acute respiratory distress acute respiratory syndrome alveolar cell Anti-inflammatory anti-inflammatory drug antiviral drug B cell candidate cascade caused cells characterized Chronic diseases Complication complications coronavirus Coronavirus disease 2019 counter COVID-19 COVID-19-related complications cytokine Cytokine storm drug drugs dysregulated effective elevated event function Genomics hypercytokinemia Hyperinflammatory IL-1 IL-6 Immune cell Immunity immunological pathways immunomodulatory drug immunomodulatory drugs immunopathology Implications incidence Inflammatory Inflammatory cytokines Inflammatory marker inflammatory monocyte Jak JAK/STAT signaling lung alveolar Macrophage macrophages measure mechanisms molecular mortality rate multiple organ failure pandemic pathway Pathways Pneumonia pro-inflammatory cytokine progression recruit reported review role SARS-CoV-2 secretion severely ill patient severity storm suppressed survival rate syndrome the cytokine storm the disease therapeutic drug Therapies TNF-α Trial viral infection with COVID-19 [DOI] 10.3390/vaccines9050436 PMC 바로가기 [Article Type] Review
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19미립자 물질 및 특발성 폐 섬유증에 의한 ACE2 및 TMPRSS2의 상향 조절: 심각한 COVID-19의 잠재적 역할Research Published on 2021-03-112022-09-10 Journal: Particle and Fibre Toxicology [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 Air pollution alveolar cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Bleomycin blocked caused Cell co-expressed COVID-19 COVID-19 disease COVID-19 disease severity CXCR1 Deletion Deterioration entry of SARS-CoV-2 enzyme expressing expression expression level fibroblast fibroblasts fibrosis homologue Idiopathic pulmonary fibrosis IL-8 inhibitor involved IPF lung lung alveolar lung tissue lung tissues mechanism molecular murine Particulate matter pathway patients poor prognosis prevented Protein pulmonary fibrosis receptor Reparixin Result risk SARS-COV-2 infection Serine severe COVID-19 severity specific protein suggested supplementary material These data tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Treatment upregulated upregulating were also expressed [DOI] 10.1186/s12989-021-00404-3 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링Review Published on 2021-02-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus [DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review
Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19중증 COVID-19에서 키닌-칼리크레인 시스템의 약리학적 억제와 관련된 안전성 및 결과Article Published on 2021-02-162022-09-10 Journal: Viruses [Category] 신약개발, [키워드] accumulation ACE2 angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 approved Autopsies Autopsy Blood bradykinin case control study catalytic activity Cell cells cellular changes in Clinical improvement Cohort component components Compound Computed tomography coronavirus coronavirus disease coronavirus disease 19 COVID-19 develop Dexamethasone diffusion disease disease severity edema enzyme eosinophils Evidence expressed Hypoxemia Icatibant Inflammation Inflammatory inhibition inhibitor interfere Kallikrein lung lung alveolar marker Mortality Patient pharmacological promoted receptor reduce mortality respiratory Safe Safety SARS-CoV-2 SARS-COV-2 infection severe cases severe COVID-19 severe respiratory syndrome shown System tested Treatment [DOI] 10.3390/v13020309 PMC 바로가기 [Article Type] Article